Split thickness skin grafting is a technique that has been around for a long time… because it works! With a skin graft, the surgeon will take a partial thickness piece of skin (usually from the thigh) and transplant it to the wound bed. This procedure is done in the operating room. There will be a new wound on the thigh that will need to heal. If successful, the skin graft will take and can lead to wound healing in as little as two weeks.